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KMID : 0525720090140040208
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Journal of Chitin and Chitosan
2009 Volume.14 No. 4 p.208 ~ p.213
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Effect of the Antimicrobial Activity of Chitosan Derivatives with Amino and Carboxyl Group
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Kim Ji-Min
Lee Kyung-Won
Na Jae-Sik
Chung Suk-Jin
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Abstract
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Water-soluble Chitosans, CsAa CsAam, were prepared by grafting acrylic acid and acrylamide on an amino group of chitosan (Cs), and identified the structure of grafted chitosan using 1H-NMR and FT-IR. The chitosan derivatives were used to improve the solubility of chitosan in water. The deacetylation degree of the chitosan was 91.2%. The viscosity-average molecular weights of Cs, CsAa, and CsAam were 5.36 × 105, 6.76 × 105, and 1.78 × 106, respectively. Good antibacterial effects of chitosan derivatives with three types of bacteria (that is, Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli ) is Cs < CsAa < CsAam.
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KEYWORD
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chitin, chitosan, chitosan derivatives, antimicrobial activity, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli
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